Physiology
Gastrointestinal
Question 16 of 180
Secretin secretion is stimulated by which of the following:
Answer:
Secretin secretion is stimulated by:- A low pH in the duodenum
- The presence of the products of fat digestion in the duodenum
Secretin
Physiology / Gastrointestinal / Pancreas
Last Updated: 21st April 2019
Secretin is secreted by S-cells in the duodenum.
Stimulating Factors
Secretin secretion is stimulated by:
- A low pH in the duodenum
- The presence of the products of fat digestion in the duodenum
Inhibitory Factors
Secretin release is inhibited by somatostatin.
Function
Secretin acts to:
- Decrease gastric acid secretion by gastric parietal cells (through inhibition of gastrin release)
- Inhibit gastric emptying
- Stimulate the release of pepsinogen by gastric chief cells
- Stimulate pancreatic HCO3- secretion
- Potentiate cholecystokinin-induced stimulation of pancreatic enzyme secretion
- Stimulate HCO3- and H2O secretion by the liver and increase bile production
| Hormone | Released from: | Stimulated by: | Inhibited by: | Acts to: |
|---|---|---|---|---|
| Gastrin | G-cells in the pyloric antrum | The presence of small peptides and amino acids in the stomach, gastric distension, raised gastric pH, vagal stimulation | Low gastric pH, somatostatin, secretin, cholecystokinin, gastric inhibitory polypeptide | Stimulate acid secretion from gastric parietal cells, stimulate pepsinogen from gastric chief cells, increase gastric motility, stimulate growth of gastric mucosa |
| Cholecystokinin (CCK) | I-cells in the duodenum and jejunum | The presence of fatty acids/monoglycerides and small peptides/amino acids in the duodenum | Somatostatin | Increase production of bile, stimulate release of stored bile, increase pancreatic bicarbonate secretion, stimulate pancreatic enzyme secretion, inhibit gastric emptying, inhibit gastric acid production, stimulate pepsinogen secretion |
| Secretin | S-cells in the duodenum | A low pH and the presence of fatty acids in the duodenum | Somatostatin | Inhibit gastric acid secretion, inhibit gastric emptying, stimulate pepsinogen secretion, stimulate pancreatic bicarbonate secretion, increase pancreatic enzyme secretion, increase bile production |
| Gastric inhibitory polypeptide (GIP) | K-cells in the duodenum and jejunum | The presence of fatty acids, amino acids and orally administered glucose in the duodenum | Somatostatin | Inhibit gastric acid secretion, stimulate insulin release |
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- Biochemistry
- Blood Gases
- Haematology
| Biochemistry | Normal Value |
|---|---|
| Sodium | 135 – 145 mmol/l |
| Potassium | 3.0 – 4.5 mmol/l |
| Urea | 2.5 – 7.5 mmol/l |
| Glucose | 3.5 – 5.0 mmol/l |
| Creatinine | 35 – 135 μmol/l |
| Alanine Aminotransferase (ALT) | 5 – 35 U/l |
| Gamma-glutamyl Transferase (GGT) | < 65 U/l |
| Alkaline Phosphatase (ALP) | 30 – 135 U/l |
| Aspartate Aminotransferase (AST) | < 40 U/l |
| Total Protein | 60 – 80 g/l |
| Albumin | 35 – 50 g/l |
| Globulin | 2.4 – 3.5 g/dl |
| Amylase | < 70 U/l |
| Total Bilirubin | 3 – 17 μmol/l |
| Calcium | 2.1 – 2.5 mmol/l |
| Chloride | 95 – 105 mmol/l |
| Phosphate | 0.8 – 1.4 mmol/l |
| Haematology | Normal Value |
|---|---|
| Haemoglobin | 11.5 – 16.6 g/dl |
| White Blood Cells | 4.0 – 11.0 x 109/l |
| Platelets | 150 – 450 x 109/l |
| MCV | 80 – 96 fl |
| MCHC | 32 – 36 g/dl |
| Neutrophils | 2.0 – 7.5 x 109/l |
| Lymphocytes | 1.5 – 4.0 x 109/l |
| Monocytes | 0.3 – 1.0 x 109/l |
| Eosinophils | 0.1 – 0.5 x 109/l |
| Basophils | < 0.2 x 109/l |
| Reticulocytes | < 2% |
| Haematocrit | 0.35 – 0.49 |
| Red Cell Distribution Width | 11 – 15% |
| Blood Gases | Normal Value |
|---|---|
| pH | 7.35 – 7.45 |
| pO2 | 11 – 14 kPa |
| pCO2 | 4.5 – 6.0 kPa |
| Base Excess | -2 – +2 mmol/l |
| Bicarbonate | 24 – 30 mmol/l |
| Lactate | < 2 mmol/l |
