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Time Completed: 02:21:09

Final Score 80%

144
36

Questions

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Microbiology

Principles

Question 12 of 180

Which of the following microbes is transmitted via a vector:

Answer:

Plasmodium falciparum is spread via a vector  - the female Anopheles mosquito. Treponema pallidum is spread via direct skin contact or sexual transmission. Clostridium perfringens is spread via the oral-faecal route or direct skin contact. Vibrio cholerae is spread via the oral-faecal route. Mycoplasma tuberculosis is spread via the airborne route.

Sources and Spread of Infection

Sources of Infection

Infection is caused either by organisms from the host's normal flora (endogenous infection) or by organisms transmitted from another source (exogenous infection).

Endogenous infection will only occur if circumstances permit. For example:

  • Inhalation of stomach contents may cause aspiration pneumonia.
  • Staphylococcus aureus normally found in the nose may cause infection if inoculated into a surgical wound or cannulation site.
  • N.B. Neutropenic patients are especially prone to infection from conditional pathogens.

Examples of exogenous infections include:

  • Salmonella enterica spread via ingested poultry.
  • Legionella pneumophila spread via poorly maintained air-conditioning cooling towers.

Spread of Infection

Examples of routes of transmission of infection include:

Route of Transmission Examples
Airborne Mycoplasma tuberculosis, Measles virus
Respiratory droplet Neisseria meningitidis, Influenza virus
Faecal-oral Salmonella enterica, Campylobacter jejuni
Sexual Neisseria gonorrhoea, HIV
Vector-borne Plasmodium falciparum
Transcutaneous (through intact skin) Leptospira spp., Treponema pallidum
Percutaneous (through breached skin) Staphylococcus epidermidis

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  • Biochemistry
  • Blood Gases
  • Haematology
Biochemistry Normal Value
Sodium 135 – 145 mmol/l
Potassium 3.0 – 4.5 mmol/l
Urea 2.5 – 7.5 mmol/l
Glucose 3.5 – 5.0 mmol/l
Creatinine 35 – 135 μmol/l
Alanine Aminotransferase (ALT) 5 – 35 U/l
Gamma-glutamyl Transferase (GGT) < 65 U/l
Alkaline Phosphatase (ALP) 30 – 135 U/l
Aspartate Aminotransferase (AST) < 40 U/l
Total Protein 60 – 80 g/l
Albumin 35 – 50 g/l
Globulin 2.4 – 3.5 g/dl
Amylase < 70 U/l
Total Bilirubin 3 – 17 μmol/l
Calcium 2.1 – 2.5 mmol/l
Chloride 95 – 105 mmol/l
Phosphate 0.8 – 1.4 mmol/l
Haematology Normal Value
Haemoglobin 11.5 – 16.6 g/dl
White Blood Cells 4.0 – 11.0 x 109/l
Platelets 150 – 450 x 109/l
MCV 80 – 96 fl
MCHC 32 – 36 g/dl
Neutrophils 2.0 – 7.5 x 109/l
Lymphocytes 1.5 – 4.0 x 109/l
Monocytes 0.3 – 1.0 x 109/l
Eosinophils 0.1 – 0.5 x 109/l
Basophils < 0.2 x 109/l
Reticulocytes < 2%
Haematocrit 0.35 – 0.49
Red Cell Distribution Width 11 – 15%
Blood Gases Normal Value
pH 7.35 – 7.45
pO2 11 – 14 kPa
pCO2 4.5 – 6.0 kPa
Base Excess -2 – +2 mmol/l
Bicarbonate 24 – 30 mmol/l
Lactate < 2 mmol/l

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