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Physiology

Endocrine

Question 154 of 180

Regarding calcitonin, which of the following statements is CORRECT:

Answer:

Calcitonin is secreted by the parafollicular cells (C-cells) of the thyroid gland. Calcitonin is secreted in response to rising or high levels of plasma Ca2+ ions and acts to lower circulating levels of calcium. Calcitonin acts on the kidneys to inhibit renal reabsorption of calcium and phosphate and on the bones to inhibit bone resorption by osteoclasts.

Calcitonin

Physiology / Endocrine / Calcium and Bone

Last Updated: 26th July 2024

Calcitonin is secreted by the parafollicular cells (C-cells) of the thyroid gland.

Calcitonin is secreted in response to rising or high levels of plasma Ca2+ ions and acts to lower circulating levels of calcium.

Calcitonin acts on the kidneys to inhibit renal reabsorption of calcium and phosphate and on the bones to inhibit bone resorption by osteoclasts.

By OpenStax College [CC BY 3.0 , via Wikimedia Commons

Calcium and Bone Physiology. (Image by OpenStax College [CC BY 3.0 , via Wikimedia Commons)

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  • Biochemistry
  • Blood Gases
  • Haematology
Biochemistry Normal Value
Sodium 135 – 145 mmol/l
Potassium 3.0 – 4.5 mmol/l
Urea 2.5 – 7.5 mmol/l
Glucose 3.5 – 5.0 mmol/l
Creatinine 35 – 135 μmol/l
Alanine Aminotransferase (ALT) 5 – 35 U/l
Gamma-glutamyl Transferase (GGT) < 65 U/l
Alkaline Phosphatase (ALP) 30 – 135 U/l
Aspartate Aminotransferase (AST) < 40 U/l
Total Protein 60 – 80 g/l
Albumin 35 – 50 g/l
Globulin 2.4 – 3.5 g/dl
Amylase < 70 U/l
Total Bilirubin 3 – 17 μmol/l
Calcium 2.1 – 2.5 mmol/l
Chloride 95 – 105 mmol/l
Phosphate 0.8 – 1.4 mmol/l
Haematology Normal Value
Haemoglobin 11.5 – 16.6 g/dl
White Blood Cells 4.0 – 11.0 x 109/l
Platelets 150 – 450 x 109/l
MCV 80 – 96 fl
MCHC 32 – 36 g/dl
Neutrophils 2.0 – 7.5 x 109/l
Lymphocytes 1.5 – 4.0 x 109/l
Monocytes 0.3 – 1.0 x 109/l
Eosinophils 0.1 – 0.5 x 109/l
Basophils < 0.2 x 109/l
Reticulocytes < 2%
Haematocrit 0.35 – 0.49
Red Cell Distribution Width 11 – 15%
Blood Gases Normal Value
pH 7.35 – 7.45
pO2 11 – 14 kPa
pCO2 4.5 – 6.0 kPa
Base Excess -2 – +2 mmol/l
Bicarbonate 24 – 30 mmol/l
Lactate < 2 mmol/l

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