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  • Conducting System of the Heart

    Which of the following is most true of the sinoatrial node:

    >
  • Blood Supply of the Visual Pathway

    The extracranial portion of the optic nerve is supplied by which of the following blood vessels:

    >
  • Organelles of Eukaryotic Cells

    Regarding the human cell, which of the following cell organelles is responsible for digestion of defective proteins:

    >
  • Phases of the Cardiac Cycle

    You are teaching a group of medical students about cardiovascular examination. You are discussing heart sounds and the cardiac cycle. Which

    >
  • x

    Characteristics of Statistical Power

    Regarding the power of a study, which of the following statements is INCORRECT:

    >
  • Interpretation of Forest Plots

    Regarding forest plots in meta-analysis, the lateral points of the diamond represents:

    >
  • x

    Parts of the Common Bile Duct

    The retroduodenal region of the common bile duct:

    >
  • x

    Microbial Mechanisms of Attachment

    A 21 year old girl presents to ED with abdominal cramps and watery diarrhoea. Her boyfriend has recently returned from travelling abroad and

    >
  • x

    Anatomy of the Supratrochlear Lymph Nodes

    You are asked to assess a 32 year old woman who presents with a five day history of fever and right arm swelling following a cat scratch. O

    >
  • x

    Fascia of the Kidney

    A 79 year old man presents to ED complaining of fever and left sided abdominal and back pain. Imaging reveals a large perinephric abscess. W

    >
  • Disturbance of Acid-Base Balance

    Which of the following conditions is most likely to cause the following blood gas result (on air): pH = 7.34 PaO2 = 9 kPa PaCO2 =

    >
  • x

    Interpretation of Skewed Distribution

    Regarding the following data distribution, which of the following statements is CORRECT: [caption id="attachment_1107" align="alignnone"

    >
  • Production of Atrial Natriuretic Peptide

    Atrial natriuretic peptide (ANP) is primarily produced in response to:

    >
  • Measures of Spread

    Which of the following is NOT a measure of spread of data:

    >
  • Clinical Features of Phaeochromocytoma

    A 32 year old woman presents with episodes of flushing, headaches and palpitations. On examination her blood pressure is significantly eleva

    >
  • Clinical Effects of Ulnar Nerve Injury

    A 54 year old lady presents to ED having injured her left arm. She is complaining of weak hand grip of her left hand. The patient is unable

    >
  • x

    Cutaneous Innervation of the Lower Limb

    The skin over the webspace between the 1st and 2nd toe is supplied by which of the following nerves:

    >
  • Surface Anatomy of the Abdominal Aorta

    The aorta enters the abdomen at which of the following vertebral levels:

    >
  • ALS Treatment Algorithm

    In adult advanced life support, which of the following best describes the correct administration of adrenaline for a shockable rhythm:

    >
  • Pharmacological Management of Acute Asthma

    A 35 year old woman presents to ED with an acute asthma attack and you are asked to prescribe steroids. What is the most appropriate dose of

    >
  • Renal Handling of Sodium

    Which of the following hormones acts to inhibit Na+ reabsorption in the distal nephron:

    >
  • x

    Iron Deficiency Anaemia

    In iron deficiency anaemia, which of the following would you NOT expect to see:

    >
  • Function of Glucagon

    Which of the following is NOT an action of glucagon:

    >
  • >
  • x

    Structure of the Parasympathetic Nervous System

    Parasympathetic preganglionic neurons originate in which of the following locations:

    >
  • Origin of the Palmar Aponeurosis

    You have been asked to review a wound on the hand of a 42 year old gardener. He sustained a deep laceration to the right palm whilst cutting

    >
  • Function of the Stomach

    Which of the following is NOT a function of the stomach:

    >
  • Clinical Features of Diabetic Ketoacidosis

    Which of the following is NOT a typical clinical feature of diabetic ketoacidosis:

    >
  • x

    Cutaneous Innervation of the Face

    The skin of the lower central part of the forehead is primarily supplied by which of the following nerves:

    >
  • x

    Loop Diuretics: Side Effects

    Which of the following is NOT an adverse effect of furosemide:

    >
  • Microbial Mechanisms of Attachment

    Which of the following microbes attaches to host cells by its haemagglutinin antigen:

    >
  • Mechanism of Carbohydrate Digestion

    Regarding carbohydrate, which of the following statements is INCORRECT:

    >
  • x

    Lymphatic Drainage of the Testis

    A 21 year old man presents to ED complaining of a scrotal lump. Imaging demonstrates a testicular tumour. The lymphatic drainage of the test

    >
  • Function of Adrenocorticotropic Hormone

    Adrenocorticotropic hormone (ACTH) primarily acts on which of the following target organs:

    >
  • Surface Anatomy of the Pulmonary Trunk

    The pulmonary trunk bifurcates into the right and left pulmonary arteries posterior to the:

    >
  • x

    Regulation of Glucagon

    Which of the following factors increases glucagon secretion:

    >
  • Pharmacological Management of Status Epilepticus

    A 21 year old patient with known epilepsy is brought into ED by her parents in status epilepticus. You proceed to give intravenous lorazepam

    >
  • Hypersensitivity Reactions

    The early phase of type I hypersensitivity is mediated predominantly by which cell type:

    >
  • x

    Routine Immunisation Schedule

    Pneumococcal conjugate vaccine (PCV) is given at which of the following intervals in the UK routine childhood immunisation schedule:

    >
  • Function of the Adrenal Cortex

    The adrenal cortex releases which of the following:

    >
  • Mechanism of Postural Hypotension

    What is the initial physiological effect resulting in postural hypotension:

    >
  • Calculation of the Anion Gap

    You are calculating the anion gap of an unconscious patient with a metabolic acidosis. Which of the following anions are required to calcula

    >
  • Metoclopramide: Mechanism of Action

    What is the main mechanism of action of metoclopramide:

    >
  • x

    Function of the Orbital Muscles

    The lateral rectus muscle acts to produce which of the following eyeball movements:

    >
  • Control of Gastric Acid Secretion

    The secretion of hydrochloric acid by gastric parietal cells is inhibited by all of the following EXCEPT for:

    >
  • Arterial Waveforms during the Cardiac Cycle

    What does the dicrotic notch on the arterial waveform represent:

    >
  • x

    Articulations of the Tarsal Bones

    The calcaneus bone articulates with which of the following bones:

    >
  • Structure of the Inguinal Ligament

    The inguinal ligament is formed from which of the following:

    >
  • Phases of the Cardiac Cycle

    In the isovolumetric relaxation phase of the cardiac cycle, which of the following statements is INCORRECT:

    >
  • x

    Clinical Effects of Ulnar Nerve Injury

    A 48 year old presents to ED having sustained a deep laceration to his right upper limb. On examination he is unable to extend the interphal

    >
  • x

    Contents of the Femoral Sheath

    A 53 year old man presents to the ED after falling from a horse onto a fence. Imaging has shown trauma to the contents of the left femoral s

    >
  • x

    Haemolytic Anaemia

    Which of the following is NOT mainly characterised by intravascular haemolysis:

    >
  • Clinical Effects of Ulnar Nerve Injury

    A 58 year old man sustains an injury to the ulnar nerve and complains of sensory loss. Which of the following areas of skin would you LEAST

    >
  • x

    Structure of the Orbital Septum

    A 56 year old diabetic man presents to ED with a fever and a painful swollen eye. You diagnose periorbital cellulitis. What anatomical struc

    >
  • Attachments of the Flexor Carpi Ulnaris Muscle

    A patient presents with weakness of the left forearm and hand. You examine the strength of the muscles in the anterior forearm. The flexor c

    >
  • NSAIDs: Pharmacology

    Regarding NSAIDs, which of the following statements is CORRECT:

    >
  • Definition of Henry's Law

    Which of the following describes the relationship between the partial pressure of a gas and the amount of that gas that will dissolve in a l

    >
  • Water Absorption in the Small Intestine

    Whilst on working an elective in Nigeria a patient presents to hospital with profuse watery diarrhoea. Your supervising consultant suspects

    >
  • Transmission of Mycobacterium Tuberculosis

    You are alerted that a patient with known active tuberculosis has presented to ED. How is tuberculosis primarily transmitted:

    >
  • x

    Characteristics of the Pulmonary Circulation

    Regarding the pulmonary circulation, which of the following statements is CORRECT:

    >
  • x

    Control of Exocrine Pancreas Secretion

    Pancreatic ductal alkaline fluid secretion is mainly stimulated by which of the following hormones:

    >
  • x

    Inflammatory Mediators

    Which of the following is NOT an effect of cytokine activity:

    >
  • Origin of the Musculocutaneous Nerve

    A 32 year old man presents to the ED following an altercation during which he received a stab wound to the right axilla. You suspect a muscu

    >
  • Propofol: Side Effects

    Which of the following is NOT a typical side effect of propofol:

    >
  • x

    Increased vs Normal Anion Gap

    Which of the following is typically a cause of a normal anion gap metabolic acidosis:

    >
  • x

    Clinical Features of Malaria

    A 35 year old Nigerian woman presents to ED with a high fever and rigors. She has recently returned from a trip to visit family in her home

    >
  • Calculation of Cardiac Output

    The cardiac output in a healthy adult male at rest is usually about:

    >
  • Anatomy of the Pleura

    Regarding the pleura, which of the following statements is CORRECT:

    >
  • Muscle Relaxants: Pharmacology

    Regarding muscle relaxant drugs, which of the following statements is CORRECT:

    >
  • x

    Clinical Features of Influenza

    Regarding influenza, which of the following statements is INCORRECT:

    >
  • x

    Branches of the Mandibular Nerve

    A patient with known trigeminal neuralgia presents to ED with worsening symptoms. He complains of pain in his jaw radiating to his ear. Whic

    >
  • Movements of the Shoulder Joint

    A 35 year old woman was involved in a road traffic accident 8 weeks ago, where she suffered a fracture of the lateral border of the scapula.

    >
  • Clinical Effects of Axillary Nerve Injury

    A rugby player has injured his left shoulder during a match. He has anaesthesia on the skin on the lower part of the deltoid muscle. Which m

    >
  • x

    Anatomy of the Hard Palate

    Regarding the hard palate, which of the following statements is CORRECT:

    >
  • Clinical Features of Hyperthyroidism

    A 45 year old woman complains of weight loss, palpitations and heat intolerance. On examination you note tachycardia, finger clubbing and ey

    >
  • Function of the Pituitary Gland

    Which of the following hormones originates in the anterior pituitary:

    >
  • Anatomical Relations of the Rectum

    The rectovesical fascia is located at which of the following sites:

    >
  • Management of Tachyarrhythmias

    What is the initial dose of adenosine recommended for management of a regular narrow-complex tachycardia:

    >
  • Ketamine: Mechanism of Action

    Your consultant decides to use ketamine for a patient requiring procedural sedation in the Emergency Department. At what receptor does ketam

    >
  • x

    Cutaneous Innervation of the Face

    The skin of the upper forehead extending back to the middle of the scalp is primarily supplied by which of the following nerves:

    >
  • Functional Anatomy of the Nephron

    The renal corpuscle, consisting of the Bowman's capsule and the glomerulus is found where in the kidney:

    >
  • x

    Components of Normal Bacterial Flora

    Which of the following is NOT typically present in the nasopharyngeal flora:

    >
  • Branches of the Mandibular Nerve

    The inferior alveolar nerve supplies all of the following EXCEPT for the:

    >
  • Causative Agents of Ophthalmia Neonatorum

    A full term 6 day old neonate is brought in with a unilateral eye purulent discharge which the parents noticed earlier that day. On gram sta

    >
  • Clinical Features of Graves' Disease

    Which of the following clinical features is NOT typical of Graves' disease:

    >
  • Production of Secretin

    Secretin secretion is stimulated by which of the following:

    >
  • Compartments of the Peritoneal Cavity

    Which of the following best describes the location of the omental bursa:

    >
  • Calculation of the Filtration Fraction

    The normal glomerular filtration fraction in a healthy adult is about ______ %:

    >
  • x

    Clinical Effects of Hyperkalaemia

    Which of the following is an ECG change typically associated with hyperkalaemia:

    >
  • Structure of the Glomerulus

    Mesangial cells surround the glomerular capillaries and act to perform all EXCEPT which of the following functions:

    >
  • x

    Loperamide: Mechanism of Action

    Loperamide acts on which of the following types of receptors:

    >
  • Dermatomal supply of the Upper Limb

    A 32 year old motorcyclist has been brought in following a head on collision with a car. Following initial resuscitation, you are performin

    >
  • Types of Vaccines

    Which of the following is an example of a vaccine produced from polysaccharide extract:

    >
  • x

    Incomplete Lesions of the Spinal Cord

    A 24 year old builder is brought into ED following an accident at work in which a tool has fallen on his head causing a flexion injury. He h

    >
  • x

    Complications of Rubella

    A pregnant patient presents to ED with a new onset rash which started on her face and spread to her body. She has recently been in contact w

    >
  • Dermatomal Supply of the Upper Limb

    Your consultant asks you to perform a neurological assessment of a trauma patient. The patient fell approximately 4 metres on a building si

    >
  • x

    Control of Defaecation

    Which of the following actions does NOT facilitate defaecation:

    >
  • Mechanism of Cardiac Excitation-Contraction Coupling

    In cardiac myocyte excitation-contraction coupling, Ca2+ is released from which of the following organelles:

    >
  • x

    Blood Groups

    Regarding blood groups, which of the following statement is CORRECT:

    >
  • Function of the Orbital Muscles

    The inferior oblique muscle acts to produce which of the following eyeball movements:

    >
  • x

    Types of Data

    Which of the following is an example of continuous data:

    >
  • x

    Management of Tetanus-Prone Wounds

    A nurse practitioner working in minors is concerned about a patient's wound and asks for your advice. All of the following are considered to

    >
  • Iron Requirements

    Regarding iron handling, which of the following statements is CORRECT:

    >
  • Heparin: Comparison of Drugs

    Which of the following is NOT a benefit of low molecular weight heparin (LMWH) over unfractionated heparin (UFH) therapy:

    >
  • Function of the Gluteus Maximus Muscle

    A 21 year old man received a stab wound to the posterior part of his gluteal region. Following resuscitation, he is found to have great diff

    >
  • x

    Innervation of the Orbicularis Oculi Muscle

    You are examining a patient who presented with facial weakness. You note weakness of the orbicularis oculi muscle. The orbicularis oculi mus

    >
  • Microbial Mechanisms of Attachment

    Which of the following microbes adheres to the genital mucosa using fimbriae:

    >
  • Function of Secretin

    Which of the following is NOT a function of secretin:

    >
  • Clinical Features of Hyperthyroidism

    Which of the following clinical features is NOT a typical feature of hyperthyroidism:

    >
  • x

    Anatomy of the Parotid Gland

    Regarding the parotid gland, which of the following statements is INCORRECT:

    >
  • x

    Function of Calcitonin

    Calcitonin acts to bring about which of the following changes:

    >
  • Propofol: Mechanism of Action

    A 47 year old woman requires procedural sedation for DC cardioversion of atrial fibrillation. You plan to use propofol. Sedation is more lik

    >
  • x

    Surface Anatomy of the Colon

    The sigmoid colon extends as low as which of the following vertebral levels:

    >
  • Openings of the Diaphragm

    Which of the following structures pass through the oesophageal opening in the diaphragm:

    >
  • Functional Anatomy of the Kidney

    The renal pelvis is continuous distally with which of the following structures:

    >
  • Innervation of the Fibularis Longus Muscle

    The fibularis longus muscle is innervated by which of the following nerves:

    >
  • Clinical Features of Herpes Simplex Encephalitis

    Herpes simplex encephalitis has a predilection for which of the following sites:

    >
  • x

    Clinical Features of Shingles

    Regarding shingles, which of the following statements is CORRECT:

    >
  • Definition of Einthoven's Triangle

    Regarding Einthoven's triangle, which of the following statements is CORRECT:

    >
  • x

    Cutaneous Innervation of the Face

    You are testing the sensation of the face in a patient who presented with facial droop. Which of the following nerves supplies the skin abov

    >
  • Blood Supply of the Heart

    A 61 year old patient presents to ED with sudden onset central crushing chest pain. ECG demonstrates a STEMI and bradycardia with a heart ra

    >
  • x

    Human Normal Immunoglobulin: Indications

    Human normal immunoglobulin are used primarily to confer protection against which of the following infectious diseases:

    >
  • x

    Function of Calcitonin

    Which of the following is a primary action of calcitonin:

    >
  • Autoregulation of Renal Blood Flow

    Regarding renal autoregulation, which of the following does NOT cause vasoconstriction:

    >
  • x

    Obstructive vs Restrictive Lung Disease

    A patient with known lung fibrosis presents to ED with worsening breathlessness. You are reviewing her most recent lung function tests. Whic

    >
  • x

    Origin of the Femoral Artery

    A 35 year old woman presents to the Emergency Department with a painful swelling in her left groin. She is an intravenous drug user who regu

    >
  • x

    Haemolytic Anaemia

    Which of the following clinical features is NOT a typical feature of haemolytic anaemias:

    >
  • Production and Function of Saliva

    Regarding saliva, which of the following statements is CORRECT:

    >
  • Function of Angiotensin II

    Where does angiotensin II directly act on the renal nephron:

    >
  • Function of Parathyroid Hormone

    Which of the following is NOT an action of parathyroid hormone (PTH):

    >
  • x

    Coagulation Cascade

    Regarding the coagulation cascade, the intrinsic pathway requires which of the following clotting factors:

    >
  • x

    Aciclovir: Pharmacology

    Regarding aciclovir, which of the following statements is INCORRECT:

    >
  • x

    Supply of the Femoral Artery

    A 32 year old man presents to the ED after falling through a glass door. He has sustained a deep laceration to the thigh. Imaging shows a so

    >
  • x

    Clinical Effects of Shoulder Joint Dislocation

    A 28 year old man is brought to ED with a severely painful arm after being involved in a collapsed scrum during a rugby match. An x-ray of h

    >
  • Mechanism of Synaptic Transmission

    Regarding the synapse, which of the following statements is CORRECT:

    >
  • Definition of Pathogen

    Which of the following best describes a pathogen:

    >
  • x

    Routine Immunisation Schedule

    Regarding the UK selective immunisation schedule, which of the following statements is INCORRECT:

    >
  • Cutaneous Innervation of the Face

    A 45 year old man presents to ED with Hutchinson's sign; a vesicular rash on the tip of the nose. You are concerned about the possibility of

    >
  • Heart Sounds during the Cardiac Cycle

    The second heart sound is caused by which of the following:

    >
  • Propofol: Pharmacology

    Regarding propofol, which of the following statements is CORRECT:

    >
  • Megaloblastic Anaemia

    Regarding vitamin B12 requirements, which of the following statements is CORRECT:

    >
  • Pathway of the Gag Reflex

    Which of the following nerves is the afferent pathway of the gag reflex:

    >
  • x

    Innervation of the Pectoralis Minor Muscle

    An 18 year old man presents to the Emergency Department following a rugby match. He is complaining of pain over his left shoulder and is una

    >
  • Microbial Mechanisms of Immune Evasion

    Which of the following microbes has a polysaccharide capsule:

    >
  • Generation of an Action Potential

    Regarding the neuronal action potential, which of the following statements is CORRECT:

    >
  • x

    Clinical Effects of Facial Nerve Leison

    A 45 year old lady presents to ED with right sided facial weakness. Your consultant suspects a facial nerve palsy. Which of the following c

    >
  • Pharmacological Management of Status Epilepticus

    After what time period should pharmacological treatment be commenced in a patient with an ongoing convulsive seizure:

    >
  • Properties of the Resting Membrane Potential

    The membrane threshold potential for a neurone, at which point an action potential can occur, is usually about:

    >
  • Lithium: Drug Interactions

    Which of the following classes of drugs may predispose to lithium toxicity:

    >
  • x

    Exclusion Period for Chickenpox

    What is the school exclusion period for chickenpox:

    >
  • x

    Clinical Effects of Hypokalaemia

    A 29 year old man presents to the Emergency Department complaining of fatigue and muscle cramps. He is found to be hypokalaemic. A 12-lead E

    >
  • x

    Boundaries of the Femoral Ring

    A 87 year old woman presents to the ED after her carers noted she was complaining of pain in the right groin. On examination you note a tend

    >
  • >
  • Antiemetics: Pharmacology

    Regarding antiemetics, which of the following statements is INCORRECT:

    >
  • x

    Structure of the Urinary Bladder

    The ureters enter the bladder through which of the following:

    >
  • x

    Aminoglycosides: Mechanism of Action

    What is the mechanism of action of aminoglycoside antibiotics:

    >
  • Clinical Effects of Frontal Lobe Lesion

    A 69 year old patient is brought to ED with acute onset facial weakness on the right side, and difficulty with speech. He is able to respond

    >
  • Function of the Loop of Henle

    In which part of the loop of Henle is Na+ reabsorbed via the Na+/K+/2Cl- symporter:

    >
  • Homeostasis and Feedback Loops

    Regarding homeostasis, which of the following statements is CORRECT:

    >
  • Microstructure of the Cardiac Myocyte

    Action potentials are transmitted from myocyte to myocyte via which of the following:

    >
  • Functional Anatomy of the Pituitary Gland

    Which of the following statements regarding the pituitary gland is CORRECT:

    >
  • Characteristics of Klebsiella Spp.

    Regarding Klebsiella spp. which of the following statements is CORRECT:

    >
  • Anatomical Relations at the Thoracic Inlet

    A 47 year old presents to ED complaining of left hand pain. She has recently fractured her left clavicle which was treated conservatively. O

    >
  • Calculation of Mean Arterial Pressure

    Which of the following best describes the mean arterial pressure (MAP):

    >
  • Anatomy of the Thymus Gland

    Regarding the thymus gland, which of the following statements is INCORRECT:

    >
  • Clinical Features of Encephalitis

    A 19 year old patient is brought to ED with acute onset confusion, headache, and fever worsening over the past few days. You note a crusted

    >
  • x

    Increased vs Normal Anion Gap

    Which of the following is typically a cause of an increased anion gap metabolic acidosis:

    >
  • Phases of the Cardiac Cycle

    Regarding the cardiac cycle, which of the following statements is INCORRECT:

    >
  • x

    Haemophilia

    Haemophilia B results from a deficiency in:

    >
  • Innervation of the Quadriceps Femoris Muscle

    You are examining a 65 year old man who presents with left leg weakness. You note a loss of power to the left quadriceps femoris muscles. Th

    >
  • x

    Structure of the Uterine Tube

    Regarding the uterine tubes, which of the following statements is CORRECT:

    >
  • x

    Function of the Psoas Major Muscle

    A 76 year old woman presents with left flank pain and fever. A CT scan has shown a psoas abscess. The psoas major muscle acts primarily to p

    >
  • x

    Types of Data

    Which of the following is an example of discrete data:

    >
  • x

    Surface Anatomy of the Pulmonary Trunk

    The pulmonary trunk arises from the conus arteriosus of the right ventricle at which of the following locations:

    >
  • Pathogenesis of Tetanus

    Regarding Clostridium tetani, which of the following statements is CORRECT:

    >
  • Transmission of Streptococcus Pyogenes

    Streptococcus pyogenes is transmitted via which route:

    >
  • x

    Function of the Obturator Externus Muscle

    A 19 year old man self presents to the ED following a fight in a nearby street. He has sustained multiple stab wounds and lacerations to the

    >
  • Adrenaline: Side Effects

    Which of the following is NOT an effect of adrenaline:

    >
  • Function of the Loop of Henle

    Which part of the loop of Henle is impermeable to water:

    >
  • Organelles of Eukaryotic Cells

    You are seeing a child with known mitochondrial disease who has presented breathlessness and cough. Which of the following best describes th

    >
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